Please use the sharing tools found via the email icon at the top of articles. Copying articles to share with others is a breach of FT.com T&Cs and Copyright Policy. to buy additional rights. Subscribers may share up to 10 or 20 articles per month using the gift article service. More information can be found at Scientists have created hybrid embryos containing both human and sheep or pig cells in an early step toward growing human organs in farm animals before transplanting them into patients.
Researchers from the US and Japan have succeeded in using stem cell and genomic editing technologies to transfer human cells into freshly generated sheep and goat embryos. They told the American Association for the Advancement of Science in Austin on Sunday that the chimeras, which contain cells from both species, developed for up to three weeks.
Hiro Nakauchi, who pioneered the research at the University of Tokyo, grew a mouse with a rat pancreas and a rat with a mouse pancreas. When cells from the rat-grown mouse pancreas were transplanted into a diabetic mouse, they made enough insulin to cure the condition without being rejected.
“The next step was to move into large animals,” Dr Nakauchi said. “This was prohibited in Japan so I decided to move to Stanford University in California to work with Professor Pablo Ross.”
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